Motor Control in Parkinsons's Disease
Roland Suri
Institut für Automatik Band 5
1. Auflage 1996
242 Seiten, Format 16 x 23 cm, broschiert
CHF 77.00 / EUR 47.40 (D)
ISBN 978-3-7281-2391-6
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This book introduces basic concepts of human motor control and focuses on the function of the basal ganglia in voluntary aiming movements.
A motor test is presented which allows to access Parkinsonian symptoms. The motor test was applied to estimate individually the pharmacodynamics of the medicament l-DOPA in Parkinsonian patients. A mathematical model on the basis of known anatomical connections of basal ganglia, motor cortex and spinal cord is developed. It is shown by computer simulations that dopamine depletion can produce tremor, reduced movement gain, bradykinesia and akinesia which agrees with origin and symptoms of Parkinson's disease. The model explains also origin and symptoms of further basal ganglia disorders as Huntington's disease and hemiballism. The model parameters are estimated for Parkinsonian patients and compared with parameters of control persons. It is shown that the synaptic gains in the basal ganglia of Parkinsonian patients differ significantly from normal values. These differences were partially restored with the l-DOPA therapy. The proposed model implies that limb specific parameters are stored in basal ganglia-thalamocortical loops, which are necessary for a proper control of movement.The book explains basic neurological concepts of basal ganglia disorders in a compact mathematical language and gives an overview about related literature.
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